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σ-共核蛋白在帕金森疾病中的功能

The Role of σ- synuclein in Parkinson's Disease
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摘要 介绍了σ-共核蛋白的来源、结构,分析了对帕金森疾病有关键作用的多巴胺合成方面的σ-共核蛋白的调节作用,并探讨了σ-共核蛋白如何发生聚集及发生聚集后可能会造成PD的发生,最后重点讨论了α-共核蛋白引起PD的多巴胺能神经元变性的作用。 Firstly, the source, structure of σ-synuclein was introduced, the regulation of σ-synuclein in dopamine synthesis of Parkinson＇ s dis- ease have a crucial role, then σ-synuclein aggregation and occurrence of PD were discussed. Finally, PD dopamine neurons caused by σ-synu- clein was studied.
作者 魏大木 熊莉丽 郝静 茆灿泉
机构地区 西南交通大学生命科学与工程学院
出处 《安徽农业科学》 CAS 2013年第31期12335-12337,共3页 Journal of Anhui Agricultural Sciences
基金 国家自然科学基金青年基金项目(31200999) 西南交通大学青年教师科研起步项目(SWJTU11BR067)
关键词 σ-共核蛋白 σ-共核蛋白聚集 帕金森病 调节多巴胺神经元 σ-synuclein σ-synuclein aggregation Parkinson＇ s disease Dopamine neurons adjustment
分类号 S188 [农业科学—农业基础科学] Q74 [生物学—分子生物学]
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参考文献24

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二级参考文献33

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安徽农业科学
2013年 第31期

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