微生物发酵制备纤溶因子的研究进展

Review of Preparing Fibrinolytic Agents Using Fermentation Methods

血栓性疾病是目前危害人类健康的第一大健康杀手,微生物发酵制备纤溶因子安全性高,是国内外筛选特异性强的溶栓剂常用方法之一。综述了纤溶菌(或纤溶酶)来源、纤溶酶制备和溶栓发酵液的其他生物活性,并对微生物发酵制备纤溶因子的未来发展方向进行了展望。

Thrombos, one of the most harmful diseases, is harmful to human health. The method of fermentation used to prepare fibrinolytic a- gents is considered as one of the most common approaches to select effective fibrinolytic agents. The sources of fibrinolytic bacterial strains or fibrinolytic enzyme, preparation of fibrinolytic enzyme and other bioactivities of fibrinolytic fermentation were summarized. In addition, the po- tential research aims of fibrinolytic fermentation were proposed.