经鼻持续正压通气佐以肺表面活性物质治疗新生儿急性呼吸衰竭的应用观察

Application observation on nasal continuous positive airway pressure accompanied by pulmonary surfactant in treatment of neonatal acute respiratory failure

目的 观察经鼻持续正压通气佐以肺表面活性物质治疗新生儿急性呼吸衰竭的临床疗效.方法 对我院2009年9月至2013年5月采取经鼻持续正压通气佐以肺表面活性物质治疗的43例急性呼吸衰竭新生儿的临床资料进行回顾性分析,观察其疗效情况.结果 临床总有效率79.07％,死亡率9.30％;治疗24 h后,Pa02、PC02、PaOJFi02、pH、R及HR较治疗前均显著改善（P＜0.05）.结论 经鼻持续正压通气佐以肺表面活性物质治疗新生儿急性呼吸衰竭疗效确切,值得临床借鉴.

Objective To observe the clinical efficacy of nasal continuous positive airway pressure accompanied by pulmonary surfactant in treatment of acute respiratory failure in newborns.Method Retrospective analysis was conducted to study clinical data of 43 cases of neonatal acute respiratory failure in children.Result Clinical total effective rate was 79.07％,the mortality rate was 79.07％; 24 h after treatment,PaO2,PCO2,PaO2/FiO2,pH,R and HR were significantly improved than those before treatment（P ＜ 0.05）.Conclusion Nasal continuous positive airway pressure accompanied by pulmonary surfactant in treatment of acute respiratory failure in newborns has exact curative effects,worthy of clinical reference and promotion.