氨基糖苷类抗生素肾毒性及生物标志物的研究进展

Nephrotoxicity of aminoglycosides and biomarkers for early detection

由于抗菌谱广和价格便宜等原因，氨基糖苷类抗生素（AGS）广泛地用于治疗革兰阴性细菌所引起的感染。然而该类抗生素在治疗过程中有10％－20％的概率引起肾毒性，使其在临床应用中受到了一定限制。本文就氨基糖苷类抗生素所引起的肾毒性以及肾毒性的预测方法做综合性介绍，并着重介绍诊断肾毒性的生物标志物（Biomarker）。

Aminoglycosides are the most commonly used antibiotics worldwide in the treatment of Gram- negative bacterial infection. However, aminoglycosides induce nephrotoxicity in 10%-20% of therapeutic courses. The purpose of this review is to make a comprehensive introduction of the nephrotoxicity induced by aminoglycosides and its prediction methods, especially the biomarkers for early detection of nephrotoxicity.