摘要
目的 研究急性心肌梗死(AMI)患者在合并高尿酸血症(HUA)时血浆纤溶酶原激活抑制物-1(PAI-1)和蛋白Z(PZ)的变化,并探讨其意义.方法 根据血尿酸水平将AMI患者分成尿酸正常组(非HUA-AMI组)61例和高尿酸血症组(HUA-AMI组)50例,健康体检者50例为对照组;检测三组AMI患者TG、TC、LDL-C、HDL-C、PAI-1和PZ指标的变化.结果 与对照组比较,非HUA-AMI组、HUA-AMI组TG、TC、LDL-C及PAI-1明显升高,HDL-C、PZ明显降低(P〈0.001);与非HUA-AMI组比较,HUA-AMI组TG、TC、LDL-C、PAI-1升高,而HDL-C、PZ降低(P〈0.05或P〈0.001).结论 AMI合并HUA患者PAI-1活性进一步升高,PZ水平进一步下降,提示HUA可能促进血栓形成,与AMI发生、发展有关.
Objective To investigate the alteration of plasminogen activator inhibitor - 1 (PAI- 1 ) and protein Z (PZ) in acute myocardial infarction (AMI) patients accompanied by hyperuricemia (HUA) and to explore their clinical significance. Methods According to the serum uric acid levels, AMI patients were divided into 2 groups: non - HUA - AMI (61 cases) and HUA - AMI (50 cases) group. Fifty healthy adults were selected as control. The level of serum TG, TC, LDL -C, HDL- C, PAI- 1 and PZ of all patients were determined. Results The levels of serum TG, TC, LDL- C and PAI- 1 were significantly higher, while the HDL- C and PZ were significant lower (P 〈 0. 001 ) in the non - HUA - AMI and HUA - AMI groups compared with those in the control group. The levels of serum TG, TC, LDL - C and PAI- 1 were significant higher, while the HDL - C and PZ were significant lower (P 〈 0.05 or P 〈 0.001 ) in the HUA -AMI group compared with those in the non - HUA- AMI group. Conclusion The progressive alterations of PAl - 1 and PZ in AMI patients accompanied by HUA suggest that HUA may promote the thrombosis, which is associated with the occurrence and development of AMI.
出处
《中国急救医学》
CAS
CSCD
北大核心
2014年第2期153-155,共3页
Chinese Journal of Critical Care Medicine