肺痿方联合激素对结缔组织病所致间质性肺疾病临床、影像、生理综合评分的影响

Effects of Feiwei Formula Combined with Glucocorticoid on Clinical,Radiographic and Physiological Scores in Connective Tissue Disease-Associated Interstitial Lung Disease

目的观察肺痿方联合激素治疗结缔组织疾病引起的间质性肺病(CTD-ILD)的临床疗效。方法将79例患者随机分为治疗组(40例)和对照组(39例),治疗组给予醋酸泼尼松片+肺痿方治疗,对照组仅给予醋酸泼尼松片口服治疗,两组均治疗3个月。观察两组患者治疗前后临床(C)、影像(R)、生理(P)综合评分及安全性指标。结果两组患者C、R、P评分治疗后较治疗前均明显下降(P<0.01),并且治疗组下降更为明显(P<0.01)。两组均未出现明显的肝、肾功能及心电图异常。治疗过程中,对照组出现血糖升高15例、类柯兴综合征8例、骨质疏松2例、肺部感染1例,不良反应发生率为67%;而治疗组分别为8例、5例、1例、0例,不良反应发生率为35%。两组比较差异有统计学意义(P<0.01)。结论肺痿方联合激素可以改善CTD-ILD患者临床症状、体征、肺功能和影像学指标,可降低醋酸泼尼松片副反应的发生率。

Objective To observe the therapeutic effect of Feiwei Formula （formula to treat lung wilting） for connective tissue disease-associated interstitial lung disease （CTD-ILD）. Methods Totally 79 cases of CTD-ILD were randomized into the treatment group and control group, with 40 and 39 in each. The treatment group was given prednisone tablets and Feiwei Formula. The control group was given prednisone only. Both groups were treated for 3 months.-The clinical （C）, radiographic （R） and physiological （P） scores and safety indicators were observed before and after treatment in both groups. Results The C, R and P scores were significantly decreased in both groups af- ter treatment （P 〈 0.01 ）, especially in the treatment group （P 〈 0.01 ）. There was no obvious abnormality of hepatic function, renal function and ECG in both groups. There were 15 cases of hyperglycemia, 8 cases of Cushing syn- drome, 2 cases of osteoporosis and 1 case of pulmonary infection in the control group, with a side effect rate of 67%. There were 8 cases of hyperglycemia, 5 cases of Cushing syndrome, 1 case of osteoporosis and 0 case of pulmonary in- fection in the treatment group, with a side effect rate of 35%. There was a significant difference between groups in the side effect rate （ P 〈 0.01 ）. Conclusion Feiwei Formula can relieve the symptoms and signs of CTD-ILD pa- tients, improve the lung function and radiographic indicators and reduce side effect of prednisone.