摘要
目的研究老年慢性心力衰竭(chronic heart failure,CHF)患者外周血中辅助性T细胞17(Th17)的比例及白介素-17(IL-17)的变化及临床意义。方法选择老年CHF住院患者作为CHF组(n=30),同时设置对照组(n=30),利用流式细胞技术和ELISA法分别检测2组患者外周血中Th17细胞比例和IL-17的水平。结果 CHF组外周血中Th17/CD4+T细胞比例显著高于对照组[(3.83±1.04)%比(2.25±0.78)%,P<0.05];CHF组患者外周血中IL-17水平显著高于对照组[(8.97±3.06)ng/L比(6.12±2.34)ng/L,P<0.05]。结论老年CHF患者外周血中Th17细胞比例及IL-17水平升高,调节Th17细胞的治疗可能为CHF治疗提供新思路。
Objective To study the significance of the detection of Th17 and IL-17 in the peripheral blood of the elderly patients with chronic heart failure（CHF）. Methods 30 hospitalized patients with CHF（80. 90±9. 62 years old） were selected as study group, and 30 patients（78.12±8.74 years old） without CHF were selected as control group. The number of Th17 cells and IL-17 level were detected by flow cytometer method and ELISA. Results The ratio of Th17/ CD4＋T in peripheral blood of patients with CHF were higher than that of normal controls[ （ 3.83± 1.04）% vs （ 2. 25± 0. 78）%,P〈0. 05]. The IL-17 level in peripheral blood of patients with CHF was higher than that of normal controls [ （8.97±3.06 ng/L） vs（6. 12±2. 34 ng/L） ,P〈0.05 ]. Conclusions Thl7 cell and IL-17 level in peripheral blood are increased in the elderly patients with CHF. It can provide a theoretical and experimental basis for the clinical diagnosis and treatment of CHF.
出处
《实用老年医学》
CAS
2014年第1期55-57,共3页
Practical Geriatrics
