摘要
从虎耳草分离得到8个单体化合物,运用MS、IR、1H NMR和13C NMR等波谱解析方法并结合文献对照分别鉴定为:原儿茶酸(1),琥珀酸(2),桦木酸(3),原儿茶酸甲酯(4),5,7-二羟基色原酮(5),槲皮素3-O-β-L-鼠李糖苷(6),槲皮素5-O-β-D-葡萄糖苷(7),1-O-β-D-glucopyranosyl-(2S,3S,4R,8E/Z)-2-[(2'R)-2'-hydroxytetracosanoylamino)]-8-octadecene-1,3,4-triol(8)。除化合物1,2,7之外,其它化合物均为首次从虎耳草属植物中分离得到。以MTT法测试化合物对PC-3前列腺癌细胞的体外抑制作用,以平板打孔法测试提取浸膏及化合物对不同菌种的抑制作用。结果表明化合物6,7对PC-3前列腺癌细胞的生长有一定的抑制作用,化合物2对枯草芽孢杆菌有潜在的抑制作用。
Eight compounds were isolated from Saxifraga stolonifera (L.) Meerb. The compounds were identified by spectral analysis ( MS,IR, t H NMR and 13 C NMR) as 3,4-dihydroxy benzoic acid ( 1 ), amber acid (2) , bettflinic acid (3), 3,4 -Dihydroxybenzoic acid methyl ester ( 4 ), 5,7-Dthydroxyehromone ( 5 ), Quercetin 3-O-β-L-rhamnopyranoside (6) ,Quercetin 5-O-β-D-glucopyranoside (7) ,1-O-fl-D-glucopyranosyl-(2S,3S,4R,8E/Z)-2-[ (2'R)-2'-hydroxytetra- cosanoylamino) ] -8-octadecene-1,3,4-triol (8). In addition to compounds 1,2,7, other compounds were first isolated from Saxifi'aga stolonifera (L.) Meerb. Testing the compounds on PC-3 prostate cancer cells in vitro inhibition by Mq'T showed that compounds 6 and 7 had the certain inhibition to the PC-3 prostate anceer,the extracts and compounds were tested by plate diffusion method for the inhibitory effect of different strains, compound 2 on Bacillus subtilis had potential inhibition.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第1期64-68,共5页
Natural Product Research and Development
基金
贵州省中药现代化科技产业研究开发专项项目(2010-5023)
贵阳市科学技术计划项目(2010)
贵阳市科学技术计划项目(2010)
贵州省科技创新人才团队建设项目(2011-4008)
关键词
虎耳草
化学成分
抗癌活性
抑菌活性
Saxifraga stolonifera ( L. ) Meerb.
chemical constituent
anticancer activity
antibacterial activity