比格犬人工感染埃立克体病的临床研究

Clinical Investigation of Beagle's Ehrlichiosis Experimentally Produced with E.platys and E.canis

为了表述比格犬感染埃立克体 (Ehrlichia)后的临床表现 ,用已确证为E .platys和E .canis混合感染的犬血对 5条比格犬进行了人工感染 ,并对临床和血液学变化进行了观察。埃立克体病的潜伏期为 6～ 2 9天 ,其后的临床表现为急性发热、眼结膜苍白、厌食、精神沉郁、体重严重减轻、腹泻带血、多处有淤血斑点出现、6～ 45天内全部死亡。血液学变化显示血红蛋白和白细胞明显减少 (P <0 .0 0 1,P <0 .0 5 )。由此可见 ,比格犬对 2种埃立克体 (E .canis和E .platys)混合感染的敏感性很高 ,严重的临床表现与美国学者普遍认为的亚临床状态相左 ,这可能是中国Gzh981株 (E .platys)和Gzh982株 (E .canis)与国外株在毒力上的差异所致。

To elucidate the clinical aspect of Beagle's,five Beagles were inoculated with blood samples that had been proved to be positive for E.plays and E.canis.The inoculated Beagles had a latency of about 5 to 29 days,and the followed clinical appearances were characterized by acute fever,anorexia,pale mucous membranes,depression,weakness,serious weight loss,and diarrhea with blood stools.Ecchymoses and petechiae of blood commonly occurred at mulitiple sites.The death occurred as early as the sixth day and all died within 45 days,WBC counts and hemoglobin values significantly decreased(p<0.001,p<0.05).It can be seen from the results that Beagles are more susceptible to the coinfection of E.platys and E.canis,and display the acute febrile clinical presentations which are different from what American researchers considered that the Beagle's ehrlichiosis was of subclinical.The acute forms of infections in this study might also attributed to the virulence differences between Chinese strain Gzh981(E.platy),Gzh982, and foreign strains.