前列腺素E1联合金水宝胶囊治疗早期糖尿病肾病的疗效观察

Clinical Study on the Therapeutic Effect of Jinshuibao and PGE1 in the Treatment of Diabetic Nephropathy

目的观察前列腺素E1联合金水宝胶囊治疗糖尿病肾病早期的疗效观察。方法将40例糖尿病肾病患者随机分为应用前列腺素E1组(对照组)和应用前列腺素E1联合金水宝胶囊组(治疗组),每组各20例,分别检测两组患者治疗前后24 h尿蛋白排泄率、血肌酐、尿素氮。结果两组患者治疗前24 h尿微量白蛋白排泄率、尿素氮和血肌酐均无显著性差异(P>0.05)。治疗后,两组患者24 h尿微量白蛋白排泄率、血肌酐较治疗前均显著降低(P<0.01),且治疗组显著低于对照组(P<0.05),而两组尿素氮均无显著性变化(P>0.05)。结论前列腺素E1联合金水宝胶囊能更有效地降低糖尿病肾病患者24 h尿蛋白排泄率以及血肌酐。

Objective To observe the clinical effect of Jinshuibao and PGE1 in the treatment of diabetic nephropathy. Methods 40 patients diagnosed as diabetic nephropathy were divided into two groups ： treatment group （ Jinshuibao ＋ PGE1 ） and control group. Both groups were treated with PEG1 injection, but Jinshuibao ＋ PGE1 was only given in treatment group. The urine protein per 24 hours, serum creatinine, and urea nitrogen of all the patients were observed before and after the treatment. Results In two groups, there was no significant difference in the urine protein per 24 hours and serum creatinine and urea nitrogen （ P 〉 0. 05 ）. After the treatment, the urine protein per 24 hours, serum creatinine of two groups lowered significantly （ P 〈 0. 01 ） compared with control group. The urinary protein per 24 hours and serum creatinine decreased significantly after the treatment （ P 〈 0. 05 ）. The urea nitrogen of the two groups was not significant after the treatment （ P 〉 0. 05 ）. Conclusion The combined therapy with of Jinshuibao and PGE1 effectively decreases the urinary protein per 24 hours and Ser in treatment of diabetic nephropathies.