铝碳酸镁对幽门螺杆菌感染活动性胃溃疡的疗效

Hydrotalcite on the curative effect of helicobacter pylori infection with active gastric ulcer

目的：探讨铝碳酸镁对幽门螺杆菌感染活动性胃溃疡的临床疗效。方法选取2012年1月～2013年10月收治的68例幽门螺杆菌感染活动性胃溃疡患者作为研究对象，并随机分为对照组和观察组，每组34例，其中对照组采用奥美拉唑＋阿莫西林＋呋喃唑酮治疗，观察组在此基础上给予铝碳酸镁治疗，分析和比较两组的临床治疗情况。结果经治疗后发现，两组的病情均得到有效控制，其中观察组的总有效率为97.1%，幽门螺杆菌根除率为85.3%，与对照组的94.1%和82.4%比较，差异无统计学意义（P＞0.05）；另外，观察组的复发率为26.5%，明显优于对照组的61.8%，差异有统计学意义（P＜0.05）。结论给予幽门螺杆菌感染活动性胃溃疡患者常规制酸抗幽门螺杆菌联合铝碳酸镁治疗，能够保证临床疗效和幽门螺杆菌的根除率，并有效降低幽门螺杆菌感染活动性胃溃疡复发率。

Objective To study Hydrotalcite on the clinical curative effect of helicobacter pylori infection with active gastric ulcer. Methods 68 active gastric ulcer patients with helicobacter pylori infection were selected as research object from January 2012 to October 2013, and they were randomly divided into control group and observer group, 34 cases in each group. Patients in the control group adopt omeprazole, amoxicillin and furazolidone treatment. And on this basis, the patients in the observer group were given Hydrotalcite. Then analyzed and compared clinical effect of the two groups. Results After treatment, disease of the two groups was effectively controlled. the total effective rate of obserer group was 97.1%, and the helicobacter pylori eradication rate was 85.3%. Compared with 94.1%and 82.4%of the control group, difference was not significant（P〉0.05）. In addition, the observer group recurrence rate was 26.5%, which was signifycantly different from that of control group（61.8%）. The difference was significant（P 〈 0.05）. Conclusion Normal anti-acid and anti-helicobacter pylori combining with Hydrotalcite could get a good clinical curative effect（such as high Eradication rate and low recurrence rate）in the treatment of helicobacter pylori infection in patients with active gastric ulcer, which was worth to be popularized.