大环钴配合物与氨基酸类物质轴向配位快速反应动力学研究

A Kinetic Study on the Axial Coordination Fast Reaction between Amino acid Compounds and Macrocyclic Cobalt Complex

模拟维生素B12 合成了水溶性的高氯酸双氯 (5 ,7,7,12 ,14,14 六甲基 1,4,8,11 四氮杂环十四烷 )钴 (Ⅲ )配合物 ,用停流分光光度计对甘氨酸等 5种氨基酸与该配合物的轴向快速反应动力学性质进行了研究 ,探讨了它们的反应机制 ,对实验数据进行了拟合处理 ,得到预平衡步的平衡常数K和速控步的速率常数k ,并算出了预平衡步的△rH0 m,△rS0m 以及速控步的△ ≠rHm,△ ≠rSm。在实验的基础上 ,提出了维生素B12

The dichloro(5,7,7,12,14,14 hexamethyl 1,4,8,11 tetraazacyclotetradecane) Cobalt(Ш) perchlorate 〔Co(C 16 H 36 N 4)Cl 2〕ClO 4 was synthesized for the imitation of vitamin B 12 .The kinetic study on axial coordination fast reaction between 〔Co(C 16 H 36 N 4)Cl 2〕ClO 4 and five amino acid compounds at different temperatures by means of the union Giken RA 401 stopped flow was reported.The mechanism of the reaction was postulated.The equilibrium constants K of the pre equilibrium step and the rate constants k of rate determining step were evaluated.The △rH 0 m,△rS 0 m of the prequilibrium step and △ ≠rH m,△ ≠rS m of the rate determining step were also calculated.