3取代吲哚衍生物的合成(Ⅰ)

Synthesis of 3-Substituted Indole Derivatives(Ⅰ)

基于吲哚衍生物和氮杂环衍生物的抗真菌活性 ,设计合成了含有噻二唑、三氮唑、二唑等氮杂环及其相应开链硫脲结构的吲哚衍生物和吲哚希夫碱化合物共 18个 ,除化合物 2、3和 16外其余目标物未见报道 ,其结构经1H NMR、IR和MS确证 。

The increasing clinical importance of drug resistant bacterial pathogens has lent additional urgency to microbiological and antibacterial research.Eighteen new indolic derivatives containing 1,2,4 triazoles,1,3,4 thiadiazoles and their respective open chain thiosemicarbazides were synthesized for evaluating their antifungal activity.All the compounds besides 2,3,16 were reported for the first time and their chemical structures have been confirmed by means of their IR, 1H NMR,MS data.The antifungi tests of them are being in process.