慢性疼痛性别差异的静息态脑功能成像研究

GENDER-RELATED DIFFERENCES IN CHRONIC LOW BACK PAIN: A RESTING-STATE fMRI STUDY

目的:对不同性别的慢性腰背部疼痛患者静息状态下的脑功能活动进行初步研究,探讨两者之间的差异。方法:对8例男性慢性腰背部疼痛患者及8例女性慢性腰背部疼痛患者进行功能磁共振成像(function magnetic resonance imaging,fMRI)扫描,采用局部一致性(regional homogeneity,ReHo)作为指标评价局部脑区的功能活动情况。结果:男性慢性疼痛组的右侧顶叶(顶上小叶、顶下小叶、楔前叶、中央后回)、右侧颞叶(颞上回、颞中回)、左侧额叶(额上回、额中回、额叶中内侧)、双侧楔前叶、双侧扣带回后部、右侧楔叶等脑区的ReHo值较女性慢性疼痛组升高;而男性慢性疼痛组的双侧小脑扁桃体、小脑山顶、小脑山坡、小脑蚓部等脑区的ReHo值较女性慢性疼痛组减低。结论:静息状态下不同性别的慢性腰背部疼痛患者之间的脑功能活动存在差异。

Objective：To study the brain functional activity of the gender-related differences between the male and female patients with chronic low back pain in resting state.Methods：Eight male and eight female patients with chronic low back pain participated by using functional magnetic resonance imaging （fMRI） in the experiment.Resting-state fMRI data were obtained from scanning the whole brain.The regional homogeneity （ReHo） approach was applied for fMRI data analysis.Results：Compared to the female patients,increased ReHo were found in the right parietal cortex,right temporal cortex,left frontal cortex,bilateral precuneus,bilateral posterior cingulate cortex and right cuneus in the male patients; while decreased ReHo were found in the bilateral cerebellar tonsil,cerebellar culmen,cerebellar declive in the male patients with chronic low back pain.Conclusion：The brain functional activity is different between the male patients and female patients with chronic low back pain in the resting state.