摘要
目的 研究葡萄糖转运蛋白1(Gult-1)在子宫颈腺癌组织中的表达及预后分析.方法 运用免疫组织化学(EnVision)法检测Gult-1在子宫颈腺癌组织及癌旁组织中的表达.结果 在癌旁组织、子宫颈腺癌组织中,Gult-l的阳性表达率分别为2.22%(1/45)、58.67%(44/75),两组之间差异有统计学意义(x2=38.23,P=0.00);Gult-1的阳性表达率与患者年龄、组织学分类及浸润深度无关,差异均无统计学意义(均P>0.05):Gult-1的阳性表达率与肿瘤直径、组织学分级及淋巴结转移有关,差异均有统计学意义(均P< 0.05).Gult-1蛋白阳性表达患者生存率低于阴性表达,差异有统计学意义(x 2=4.27,P=0.04).结论 子宫颈腺癌组织中Gult-1的过表达预示癌组织分化低、淋巴结转移可能性大及患者预后不良.
[Abstract] Objective To study the expression of Guh-1 in cervical adenocarcinoma and prognosis analysis. Methods Gult-1 was detected by immunohistochemistry (EnVision) in cervical adenocarcinoma and cancer adjacent tissue. Results In cancer adjacent tissue and cervical adenocarcinoma, the positive rates of Guh-1 were 2.22 % (1/45), 58.67 % (44/75), respectively, and there was statistical significance between them (X2 = 38.23, P = 0.00). The expression of Guh-1 was not correlated to age, histological classification and infiltrated depth (all P 〉 0.05). However, it was correlated to tumor size, histological grade and lymphatic nodes metastasis (all P 〈 0.05). The survival rate of positive Gult-1 patients was lower than negative Gult-1 patients (X 2 = 4.27, P = 0.04). Conclusion The over-expression of Gult-1 in cervical adenocarcinoma indicates poorly differentiated cancer, the possibility of lymphatic nodes metastasis and unfavourable prognosis.
出处
《肿瘤研究与临床》
CAS
2014年第1期39-41,共3页
Cancer Research and Clinic