摘要
用生物学方法观察了人参皂甙 (GS)对大鼠外周血单核细胞分泌炎性细胞因子增龄性变化的调节作用。实验结果表明 ,老年大鼠外周血单核细胞产生白细胞介素 1、6、8的能力明显增高。老年鼠给予GS2 0～40mg·kg-1后 ,可使单核细胞分泌IL - 1和IL - 6的能力显著下降 ,但对IL - 8的影响无显著性差异。结果提示 ,炎性细胞因子与衰老的关系密切 ,抑制炎性细胞因子IL - 1和IL - 6的产生可能是人参皂甙延缓衰老的作用机制之一。
Objective:To study the influence of ginsenoside (GS) on aging changes of in flammatory cytokines in mouse monocyte. Methods:The bioassay techniques were used for determination of interlrukins(IL) activity in mouse monocyte. Results:In aged rats the levels of IL-1?IL-6 and IL-8 were significantly higher than that of young rats.After treaed with GS(10,20,40 mg/kg),the IL-1 and IL -6 content in mouse monocyte of aged rats decreased markedly. Conclusion:The levels of IL-1 and IL-6 in mouse monocyte increased with aging.GS exerted inhibitory effects on monocyte's secretion of inflammatory cytokines in aged rats.
出处
《中国中医药科技》
CAS
2001年第1期28-29,共2页
Chinese Journal of Traditional Medical Science and Technology
基金
国家自然科学基金青年基金资助项目 396 0 0 187
