WHO肺部肿瘤组织学新分类

An Introduction to New Edition of WHO Histological Typing for Lung Tumors

肺癌治疗策略的制定和终点疗效的评价有赖于准确的病理组织学分类。随着近年来的肺癌分子生物学研究进展 ,国际肺癌学会 (IASLC)多次讨论重新修订病理组织学分类的意见 ,对过去在组织学分类上存在差异的组织学类型重新进行了统一。1999年4月 ,世界卫生组织 (WHO)公布了第3版《肺和胸膜肿瘤的组织学分类》。新版肺部肿瘤分类比旧版更为详尽、明确和严格 ,与近年来肺癌分子生物学的研究成果更趋于一致 ,新分类解决了一直以来肺癌分类中存在的混乱状态 ,根据组织学来源更具体地划分出各种类型 ,对肺部肿瘤的诊断、治疗和预后判断将起到重要的指导作用。规范病理诊断标准 ,有利于促进国际间的学术交流 。

The adoption of therapeutic strategy as well as the evaluation of final therapeutic effect of lung cancer depend on accurate histological typing.With the accumulation of the advance of molecular biological research recently,several discussions focusing on revisions for histological typing of lung cancer were conducted by WHO/IASLC,aiming to clarify the previously existing divergence of the classification.In April 1999,World Health Organization(WHO)finally published the third edition of Histological Typing of Tumor of the Lung and Pleura.Compared with old edition of the typing,the new one is more detailed,accurate and strict in subtyping and is more in accord with the research achievements of the molecular biology of lung cancer.Besides,the new one resolved the ever_lasting state of confusion in histological typing of lung cancer,and made out different classifications elaborately based on histological origin,which contribute to the diagnosis,therapy and assess of prognosis.Regulating the criterions of pathological classification of the lung will prompt the international academical communication,therefore,we should apply the latest edition to our article relevant to lung cancer research field as soon as possible.