泰兴市全人群肝癌病例对照研究

Population Based Case Control Study of Primary Hepatocellular Carcinoma in Taixing Area

[目的]探讨泰兴市原发性肝癌的病因。[方法]选择360例原发性肝癌新发病例按性别、年龄和居住地进行以人群为基础1∶1配对的病例对照研究。[结果]单因素分析结果表明 ,饮沟塘水、饮酒量多、不良精神因素(受过强烈精神刺激、长期处于精神压抑状态和性格忧郁)、HBsAg阳性、肝脏病变(慢性肝炎、肝硬化)、家族肝癌史(父母、兄弟姐妹患肝癌)会增加泰兴市居民患肝癌的危险性。多因素条件Logistic回归分析结果显示 ,HBsAg阳性、慢性肝炎、肝硬化、一级亲属患肝癌和饮小麦酒量多均进入回归方程 ,其相对危险度分别为20 80、13 41、5 24、3 23和5 73。

To assess the roles of suspected etiological factors of Primary Hepatocellular Carcinoma (PHC)in Taixing area. A population based case control study including 360 cases of newly diagnosed PHC and 360 controls matched on sex,age and resident area was carried out.The results from single factor analysis showed that factors as drinking pondditch water,higher comsumption of alcohol,great spirit irritation,long term feeling constraint,melancholy temperament,HBsAg positive,chronic hepatitis,cirrhosis,family history of PHC can increase risk of PHC.Multiple conditional logistic regression analysis showed that HBsAg positive,chronic hepatitis,cirrhosis,family history of PHC and great amount of wheat wine intake all entered the regression model,with OR of 20 80,13 41,5 24,3 23 and 5 73.[Conclusion] It is necessary to prevent such above risk factors in Taixing area.