摘要
动脉粥样硬化是一种慢性炎症性疾病.动脉粥样硬化斑块破裂和血栓形成可导致急性心脑血管事件.炎性介质CD40/CD40L广泛存在于与动脉粥样硬化相关的细胞,参与斑块内炎症反应,释放促炎细胞因子,降解细胞外基质,提高促凝活性,促进动脉粥样硬化的进展和斑块易损性.干预CD40/CD40L信号系统可能成为减缓动脉粥样硬化进展和稳定动脉粥样硬化斑块的一种有效治疗策略.
Atherosclerosis is a chronic inflammatory disease.Atherosclerotic plaque rupture and thrombosis may result in cardio-cerebrovascular events.Inflammatory mediator CD40L widely exists in cells associated with atherosclerosis.They participate in plaque inflammatory response,release proinflammatory cytokines,degrade extracellular matrix,improve procoagulant activity,and promote the progression of atherosclerosis and plaque vulnerability.Intervening CD40/CD40L signaling system may become an effective treatment strategy to slow the progress of atherosclerosis and stabilize atherosclerotic plaques.
出处
《国际脑血管病杂志》
北大核心
2013年第12期947-952,共6页
International Journal of Cerebrovascular Diseases
