弓形虫感染对病毒性肝炎预后影响的初步调查

Investigation on Toxoplasma Infection Influence to the Prognosis of Virus Hepatitis

目的:调查病毒性肝炎患者中弓形虫感染情况及弓形虫感染对病毒性肝炎预后的影响。方法:对92例住院的病毒性肝炎患者采用间接血凝(IHA)方法检测弓形虫抗体,同时应用ELISA法进行弓形虫抗体IgM、IgG检测。结果:92例病毒性肝炎中4例IgM和IgG同时阳性,2例IHA1∶64,同时IgM,总感染率为6.25％。在AVH、CVH、HG、HCC中,弓形虫感染率分别为2.86％、5.26％、9.05％、16.70％、50％,其感染率随肝炎病程加重而升高。合并弓形虫感染可导致肝损害加重,其中总胆红素升高明显,与急、慢性肝炎、肝硬化相比明显增高(P<0.05)。而ALT值与慢性肝炎和肝硬化相比差异显著(P<0.01)。结论:弓形虫感染可加重病毒性肝炎的病程,延长肝功能恢复时间。

Objective : To investigate toxoplasma infection influence to the prognosis of virus hepatitis. Methods:The antibody of toxoplasma and antrlgM, IgG of toxoplasma were tested in 92 inpatients with virus hepatitis by IHA and ELISA. Result:4 patients were positive of antrlgM and IgG, 2 patients were positive of anti-IgM and IHA 1:64 in 92 patients with virus hepatitis. The total rate of toxoplasma infection was 6.5%. In AVH, CVH,LC,HG,HCC, the rate of toxoplasma infection were 2.86%, 5.26%, 9.05%, 16.70%, 50%, respectively. With the course of hepatitis worsened, the rate of infection was raised. Inpatients with virus hepatitis liver toxoplasma infection could lead the liver to more serious damage, and the TB in the patients raised much more obviously than that in patients with AVH, CVH and LC (P < 0.05), the value of ALT was higher than that in CVH and IX (P<0.01). Conclusion:Toxoplasma infection can influence the course of virus hepatitis worsen the state of hepatitis and prolonged the its recover time.