脑梗死患者血清胰岛素样生长因子-1与颈动脉粥样硬化斑块的关系

Relationship between serum levels of insulin-like growth factor-1 and carotid atheromatous plaques in patients with cerebral infarction

目的探讨脑梗死患者血清胰岛素样生长因子-1(IGF-1)与颈动脉粥样硬化斑块的关系。方法选取100例急性脑梗死患者及50例健康对照者,采用ELISA法测定血清IGF-1水平,并进行颈动脉彩超检查,根据结果分成不稳定斑块组、稳定斑块组、无斑块组三亚组。结果脑梗死组颈动脉粥样硬化斑块及不稳定斑块的检出率分别为67.0%及42.0%,均明显高于对照组26.0%和8.0%,P<0.01。不稳定斑块组的血清IGF-1水平明显低于稳定斑块组及无斑块组(均P<0.01),稳定斑块组血清IGF-1水平明显低于无斑块组(P<0.05)。结论脑梗死患者的颈动脉粥样硬化斑块发生率明显增高;血清IGF-1水平减少与不稳定性颈动脉粥样硬化斑块形成密切相关。

Objective To investigate the relationship between serum levels of insulin- like growth factor- 1（IGF- 1）and carotid atheromatous plaques in patients with cerebral infarction. Methods One hundred patients with cerebral infarction and 50 healthy subjects were enrol ed in the study. Serum IGF- 1 levels were measured by ELISA and carotid artery was examined by ultrasonography in both groups. Patients with unstable plaque, stable plaque and non- plaque were classified by ultrasonic find-ings. Results The rate of carotid atheromatous plaque and unstable plaque in cerebral infarction patients were 67.0% and 42.0%respectively, which were significantly higher than that in control group （26.0% and 8.0%, P〈0.01）. Serum IGF- 1 level in unstable plaque group was significantly lower than that in stable plaque group and non- plaque group （P〈0.01）; while serum IGF- 1 level in stable plaque group was significantly lower than that in non- plaque group（P〈0.05）. Conclusion The incidence of carotid atheromatous plaque in patients with cerebral infarction is markedly increased; which is associated with the decreased serum IGF- 1 levels in patients.