系统性红斑狼疮及系统性硬化症的血液学异常分析

The hematology abnormality in systemic lupus erythematosus and progressive systemic sclerosis

目的 :研究系统性红斑狼疮 (SL E)及系统性硬化症 (PSS)的血液学异常情况 ,进一步指导诊断及鉴别诊断。方法 :回顾性分析 6 2例 SL E及 39例 PSS患者的血液学资料 ,率比较采用 χ2 检验 ,均值比较采用 t检验。结果 :以贫血最常见 ,SL E者占 77.4% ,PSS者占 17.9% ,两者比较差异有显著性意义 (P <0 .0 5 )。 SL E者血红蛋白均数显著低于 PSS者。 2 8例 SL E患者行骨髓检查 ,大部分患者骨髓增生活跃或明显活跃 ,主要表现为增生性贫血骨髓像。 18例 SL E患者行抗人球蛋白试验 ,阳性率为 6 6 .7%。结论 :风湿类疾病相关性血液学异常较常见 ,其中以贫血最为多见 ,尤以 SL E者最突出 ;骨髓主要表现为增生性贫血 ;

Objective:To study the hematology abnormality in systemic lupus erythematosus(SLE) and progressive systemic sclerosis(PSS).Methods:The hematology information of 62 SLE and 39 PSS patients were analysed retrospectively.χ 2 and t test were used in statistical analysis.Results:Anemia in 77.4 % SLE and 17.9 % PSS patients.28 SLE patients received bone marrow aspiration, most of them had hyperplasia. 18 SLE cases had received coombs test, in 66.7% were positive.Conclusions:The hematology abnormality is frequent in SLE patients.Anemia is most common; bone marrow usually are hyperplasitic; Coombs test are positive in about half patients.