梗阻性黄疸大鼠白细胞介素2受体和T细胞亚群的变化

Change of Soluble Interleukin-2 Receptor Level and Subsets (CD+4, CD+8) in Rats with Obstructive Jaundice

目的 探讨梗阻性黄疸大鼠可溶性白细胞介素 2受体 (SIL - 2R)和T淋巴细胞亚群的变化。方法 采用胆总管结扎法 (BDL)制造大鼠梗阻性黄疸模型 ;对照组 (Sham)接受同样方法但不结扎胆总管 ;内引流组在梗阻性黄疸 3周后行胆肠内置管行内引流 (ID) ,动态观察血清SIL - 2R和T细胞亚群变化。结果 ID后SIL - 2R明显升高 ,血浆CD+4 下降、CD+8升高。ID1周后SIL - 2R水平降低 ,CD+4 升高 ,CD+8下降。结论 梗阻性黄疸时 ,机体细胞免疫功能受抑 ,内引流后可改善机体免疫功能。

Objective: To investigate the change of serum soluble interleukin-2receptor (SIL-2R) level and subsets (CD+ 4, CD+ 8). Methods: Obstructive jaundice rat models were established with bile duct ligation (BDL). Sham operation received the same procedure exclusive BDL. BDL for three weeks followed by a second laparotomy and further one-week of internal drainage (ID). The change of subsets (CD+ 4, CD+ 8) and serum SIL-2R content were investigated. Results: serum SIL-2R content obviously increased, plasma CD+ 8 increased while CD+ 4 decreased after BDL. SIL-2R and CD+ 8 decreased while CD+ 4 significantly elevated after one week. Conclusion: Cellular immunity of obstructive jaundice rats was depressed and ID could effectively improve host cell immunity.