大肠癌术前动脉灌注化疗的组织学疗效分析

Histologic Analyses of Colorectal Carcinoma Treated with Preoperative Arterial Infusion Chemotherapy

［目的］评价术前肠系膜上、下动脉灌注抗癌药物治疗大肠癌的组织学疗效及其临床价值。［方法］术前病理证实的５１ 例大肠癌经选择性肠系膜上、下动脉插管灌注抗癌药物１至２次，５至３０天，平均１２天后手术切除，标本送病理切片行组织学疗 效观察。［结果］肿瘤组织学疗效０级１例，Ⅰ级２１例，Ⅱ级２４例，Ⅲ级５例，总有效率９８０％，１６例淋巴结转移，其组织学疗效０ 级５例，Ⅰ级５例，Ⅱ级５例，Ⅲ级１例，总有效率６８ ８％。［结论］术前动脉灌注抗癌药物治疗大肠癌组织学疗效显著，可降低淋巴 结转移率。

Purpose] To evaluate the histologic response and clinical value of colorectal carcinoma treated with preoperative transcatheter superior (or inferior) mesenteric artery infusion chemotherapy. [ Methods]The histologic response was evaluated in 51cases of colorectal carcinoma treated with preoperative transcatheter superior (or inferior) mesenteric artery infusion chemotherapy. All patients have preoperative pathologic diagnosis .The operation was performed 5 ~ 30day after trancatheter artery infusion with an average of 12 days. [Results]The total response rate was 98. 0% with grade 0 in 1 case, grade I in II cases, grade II in 24 cases, and grade III in 5 cases. The response rate in 16 cases with local node metastasis was 68. 8% with grade 0 in 5 cases,grade I in 5 cases, grade II in 5 cases, and grade III in 1 case. [ Conelusion] Preoperative transcatheter artery infusion chemotherapy reveals significant histologic response, and is able to decrease the rate of local node metastasis for coloractal carcinoma.