摘要
[目的]比较放、化疗与单纯放射治疗鼻咽癌的生存率、局部控制率、远处转移发生率和毒副反应。[方法]从 1991年 4 月至 1993年 10月, 126例N2、N3期鼻咽癌患者随机分入放、化疗组和常规放疗组。放、化疗组放疗前、中及(或)放疗后各用 PDD+ 5-Fu化疗一个疗程,化疗方案为 PDD20mg/m2, 1至 5天;5-Fu500mg/m21至 5天;两组放疗方法相同,全部病例用 8MV光子线及60CO 外照射,鼻咽部剂量65Gy-70Gy/6.5周-7周。颈淋巴结转移灶剂量65Gy-70Gy/6.5周-7周,颈淋巴结预防剂量50Gy/5周。 [结果]放、化疗组和单放组鼻咽肿瘤完全消退率分别为93.6 %和85.7%(P>0.05),颈部转移淋巴结完全消退率分别为84.1% 和57.1%(P<0.05);两组3年生存率分别为68.3%和52.4%(P>0.05);N2期鼻咽癌患者3年生存率分别为75.5%和58.7% (P>0.05),N3期鼻咽癌患者3年生存率分别为50. 0%和35.3%(P>0.05);3年鼻咽部肿瘤控制率两组分别为对4%和57.1% (P<0.05),颈转移淋巴结控制率分别为69.8%和52.3?
Purpose] To compare the effect of radiotherapy combined with chemotherapy and radiotherapy alone in the treatment of nasopharyngeal carcinoma. [Methods] From April 1991 to October 1993, 126 patients with histologically proved nasopharyngeal carcinoma (stage N2. N3 ) were randomized into two groups: group A (63 cases) were treated with radiochemotherapy, receiving radiotherapy of (65 ~ 70) Gy/ (6. 5 ~ 7) W to the nasoparynx and (65 ~ 70) Gy/(6.5 ~ 7) W to neck and receiving 2 ~ 3 cycles of chemotherapy with PF protocol (5-Fu and cisplatin). Group B (63 cases) received the same radiotherapy alone. [Results]The complete response rates for the primary tumor in the group A and group B were 93. 6% and 85. 7% respectively with no significant difference (P > 0 .05) .The remission in the cervical lymph 'nodes was revealed to be better in group A than that in group B, their CR rates were 84. 1 % and 57. 1 % respectively with significant difference (P < 0.05) . The 3-year survival rates of group A and group B were 68.3% and 52.4% respectively (P > 0.05). The 3-year primary tumor and cervical node control rate in group A was higher than that in group B (P < 0.05) .The 3-year survival rate of N2 stage in group A and group B were 75 .5% and 58 .7% (P > 0 .05) .The 3-year survival rate of N3 stage in group A and group B were 50.0% and 35. 3% (P > 0.05) .The distant metastasis in group A was lower than that in group B (20. 6% vs 39 .7%, P> 0.05). [Conclusion] Radiotherapy combined with chemotherapy may in- crease local disease control and may diminish distant metastasis in patients with nasopharyngeal carcinoma.
出处
《中国肿瘤》
CAS
2001年第1期50-52,共3页
China Cancer
关键词
鼻咽肿瘤
药物疗法
放射疗法
生存率
预后
nasopharyngeal neoplasms
drug therapy
radiotherapy
survival rate
prognosis