110例丙型肝炎病人HBV重叠感染的血清学分析

Serum analysis of coinfection with HBV in the 110 HCV patients.

[目的]为探讨丙型肝炎HBV重叠感染的血清状况。[方法]用TC-PC多聚酶链反应及ELISA酶链免疫吸附测定方法对110例丙型肝炎病人血清进行HCVRNA及抗-HCV检测,并用ELISA方法与对照组一同进行抗-HCV、HBsAg、抗-HBc、HBeAg检测。[结果]丙型肝炎的HBV重叠感染率为78.18％(86/110)和正常人群的HBV感染率24.60％(33/125)相比P<0.001,OR(观测率)值为9.99,ARP为90％;丙型肝炎的HBV重叠感染和单-HCV感染的抗-HCV水平(S/Co比值)均值比P<0.20,差异无显著性;HBV和HCV重叠感染其HBeAg感染率很低,和正常人群相比差异无显著性,P>0.05。而且,HBeAg的(S/Co比值)均值比差异也无显著性,P>0.05。[结论]丙型肝炎病人极易重叠感染HBV;丙型肝炎病人抗-HCV抗体水平较低,重叠感染后其HCV抗体水平不受影响;HCV与HBV重叠感染干扰抑制HBV的复制。

[Purpose]IN order to study the serum prevalence of coinfection HBV in the patients with hepatitis C. [ Methods] HCV -RNA and anti - HCV were detected in the 110 HCV patients with TC - PCR and ELISA. Anti - HCV,HBsAg,anti - HBc and HBeAg were detected together with the control Group in ELISA. [Result]The rates of HBV coinfection in the HCV patients is 78.18% (867 110) ,the rates in the normal population is 24.60% (33/125), P <0.001 ,OR(9.99) ,ARP% (90% ) .The means ofanti - HCV(S/ Co RATIO) in the HBV coinfection patients is compared with the HCV patients, P < 0.20, not significant difference; The rate of HBeAg is very low in the HBV and HCV coinfection patients.lt is compared with that of the normal population, P > 0.05, not significant difference, the means of HBeAg (S/Co RATIO) coinfection in the HCV patients is compared with the normal population, P > 0.05 . [ Conclusion] HCV patients are very easily infected by HBV. The level of anti - HCV in the HCV patients is very low, but the level is not influenced by HBV coinfection. The replication of HBV - DNA is inhibited in the HBV and HCV coinfection patients.