肝移植治疗晚期肝硬化

reatment of end-staged liver disease with liver transplantation

目的 肝移植治疗肝脏终末期病变。方法 采用改良的背驮式肝移植技术即保留肝后下腔静脉的全病肝切除 ,将供肝植于受肝原位 ,供、受体肝上下腔静脉 ,供、受体门静脉 ,供、受肝动脉行对端吻合 ;结扎供肝肝下下腔静脉。用FK5 0 6、晓悉和强的松三联免疫抑制剂抗排斥反应。加强术后监护和感染的控制。结果 例 1、例 2目前分别存活 11个月、8个月余 ,生活自理 ,例 3因术后并发急性肾功能衰竭死亡 ,存活 14d。结论 肝移植是治愈肝脏终未期病变的可靠方法。

Objective To study the effests of liver transplantation for end-staged liver disease . Method Liver transplantion was performed in three patients with end-staged liver disease .After resection of the patients liver in preservation of the recipient inferior vena cava ,the donor liver was transplanted into the patient with an end to end anastomosis of uphepatic inferior vena cava , portal vein ,hepatic artery between the donor and the recipientliver with the ligation of donor subhepatic inferior vena cava. The liver rejection was controlled by FK506 、MMF and prednisone. We monitored the patient and prevented them from infection after the operation.Results Up to now, two patients have survived for 11 and 8months respectively. The third patient died of renal failure on the 14 th days after operation. Conclusion The liver transplantation is a save and effective means of end-staged liver disease.