期刊文献+

免疫抑制剂在炎症性肠病中的治疗新进展 被引量:8

下载PDF
导出
摘要 炎症性肠病的药物治疗在过去20年里变化巨大。一项丹麦的研究显示,2003-2011年与1995-2002年相比,在克罗恩病的治疗中,美沙拉嗪的使用逐渐下降,而硫唑嘌呤和生物制剂[抗肿瘤坏死因子(TNF—α)抗体]的使用明显上升,糖皮质激素的使用没有显著变化。同期,克罗恩病的手术率也明显下降。药物治疗的变化对于患者的自然病程产生重要的影响,其中免疫抑制剂在克罗恩病治疗中的意义不容忽视。
作者 李玥 钱家鸣
出处 《中国医院用药评价与分析》 2014年第1期3-4,共2页 Evaluation and Analysis of Drug-use in Hospitals of China
  • 相关文献

参考文献6

  • 1Rougoe C, Langholz E, Andersson M, et al. Changes in medical treatment and surgery rates in inflammatory bowel disease: a nationwide cohort study 1979-2011 [ J]. Gut, 2013 : 1-10.
  • 2Dassopoulos T, Sultan S, Falck-Ytter YT, et al. American Gastroenterological Association Institute Technical Review on the Use of Thiopurines,Methotrexate,and anti-TNF-c~ Biologic Drugs for the Induction and Maintenance of Remission in inflmnmatory Crohn' s Disease [ J ]. C, astroen-terology, 2013, 145 (6) : 1464-1478.
  • 3高翔,肖英莲,陈旻湖,杨荣萍,陈白莉,胡品津.硫唑嘌呤治疗活动性克罗恩病的开放性前瞻性研究[J].中华消化杂志,2011,31(3):145-149. 被引量:20
  • 4Laharie D, Bourreille A, Branche J, et al. Cyclospor~n versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomized controlled trial [ J ]. Lancet, 2012, 380 (9857) :1909-1915.
  • 5Feagan BG, McDonald JW, Rochon J, et al. Low-dose cyclosporine for the treatment of Crohn's disease. The Canadian Crohn's Relapse Prevention Trial Investigators [J]. NEJM,1994,330(26) :1846-1851.
  • 6Lazzerini M, Martelossi S, Magazz~ G, et al. Effect of thalidomide on clinical remission in children and adoles- cents with refractory Crohn disease: a randomized clinical trial[J].JAMA ,2013,310(20) :2164-2173.

二级参考文献15

  • 1Frφslie KF,Jahnsen J,Moum BA,et al.Mucosal healing in inflammatory bowel disease:results from a Norwegian population-based cohort.Gastroenterology,2007,133:412-422.
  • 2Schnitzler F,Fidder H,Ferrante M,et al.Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease.Inflamm Bowel Dis,2009,15:1295-1301.
  • 3D'Haens GR,Fedorak R,Lémann M,et al.Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease.Inflamm Bowel Dis,2009,15:1599-1604.
  • 4Colombel JF,Sandborn WJ,Reinisch W,et al.Infliximab,azathioprine,or combination therapy for Crohn's disease.N Engl J Med,2010,362:1383-1395.
  • 5Hindorf U,Lindqvist M,Hildebrand H,et al.Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease.Aliment Pharmacol Ther,2006,24:331-342.
  • 6Gisbert JP,Gomollón F.Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease:a review.Am J Gastroenterol,2008,103:1783-1800.
  • 7Connell WR,Kamm MA,Ritchie JK,et al.Bone marrow toxicity caused by azathioprine in inflammatory bowel disease:27 years of experience.Gut,1993,34:1081-1085.
  • 8Prefontaine E,Sutherland LR,Macdonald JK,et al.Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.Cochrane Database Syst Rev,2009,(1):CD000067.
  • 9Zheng JJ,Chu XQ,Shi XH,et al.Efficacy and safety of azathioprine maintenance therapy in a group of Crohn's disease patients in China.J Dig Dis,2008,9:84-88.
  • 10Satsangi J,Silverberg MS,Vermeire S,et al.The Montreal classification of inflammatory bowel disease:controversies,consensus,and implications.Gut,2006,55:749-753.

共引文献19

同被引文献52

引证文献8

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部