解放军第371中心医院抗菌药物干预前后应用分析

Analysis of Antibiotic Use in No.371 Central Hospital of PLA before and after Clinical Intervention

目的:了解综合运用多种临床干预措施对应用抗菌药物的影响,为规范医院抗菌药物应用、探索合理干预措施管理提供依据。方法:分别调取2010及2011年我院住院患者的抗菌药物消耗数据,分别作为干预前组和干预后组,利用ABC分析法分析干预前后使用抗菌药物变化情况。结果:干预后抗菌药物销售金额总体下降明显,下降了26.46%(393.10万元/1 485.47万元),其中A类药品下降最显著,占总体下降金额的73.03%(287.07万元/393.10万元);抗菌药物销售金额占药品总销售金额的百分比有所下降,由27.15%(1 485.47万元/5 471.27万元)降至19.32%(1 092.37万元/5 655.12万元);人均抗菌药物费用显著降低,由706.10元降至500.26元;用药频度(DDDs)较高的抗菌药物限定日费用(DDC)明显下降(P<0.01),差异有统计学意义。结论:实施有效可行的临床干预措施能够提高抗菌药物使用的合理性,规范医生的用药行为,对促进安全、有效、经济地使用抗菌药物起到积极作用。

OBJECTIVE：To investigate the effect of integrated use of a variety of clinical mtervenhons on ant：bmt：c use to provide references for standardizing antibiotic use and exploring of reasonable intervention management measures. METHODS： The inpatient antibiotic consumption data in 2010 vs. 2011 in our hospital were retrieved and assigned to pre-intervention group and post-intervention group; using ABC analysis method, the antibiotic use before and after intervention was analyzed. RESULTS： After intervention the total consumption sum of antibiotics was significantly declined, down 26.46% （393.10/l 485.47, unit： 10 000 Yuan）, much as in the reduction of category A antibiotics, its reduction accounted for 73.07% of total reduction amount of money （287.07/393.10, unit： 10 000 Yuan）. The proportion of total cost of antibiotics in total drug cost decreased from 27. 15% （ 1 485.47/5 471.27, unit： 10 000 Yuan） to 19.32% （ 1 092.37/5 655. 12, unit： 10 000 Yuan）. The average cost of antibiotics per capita fell from 706.10 Yuan to 500.26 Yuan. The antibiotics with high DDDs showed a significant reduction in defined daily costs （DDC） （P 〈 0.01 ）. CONCLUSION： Implementation of effective and feasible clinical interventions contributed to improvement in clinical rational use of antibiotics, standardization of physicians＇ medication behavior, and safe, effective and economical antibiotic use.