具有视力计功能的手持式视网膜对比敏感度测量仪的研制与应用

Produce and application of a novel handheld prototype measuring retinal CSF with function of interferometer

目的研究设计具有干涉视力计功能的手持式视网膜对比敏感度（retina contrast sensitive function，RCSF）测量设备，并探究其临床测量的重复性和有效性。方法制作手持式具有干涉视力计功能的RCSF样机3台，并对48例（48眼）正常人（RCSF测量组）和20例（33眼）成熟白内障患者（干涉条纹视力测量组），分别进行2次RCSF测量和术前最佳矫正视力测量。对2组间RCSF测量差异性进行独立样本t检验，术前、术后最佳矫正视力相关性采用线性相关分析。结果在对48例正常人的2次测量中，对应空间频率2．4c·d^-1、3．6c·d^-1、6．0c·d^-1、9．0c·d^-1、15．0c·d^-1、24．0c·d^-1的前后不一致的次数分别是0次、0次、2次、4次、4次、9次，一致率分别是100％、100％、95．8％、91．7％、91．7％、81．3％。除对应空间频率24．0c·d^-1的RCSF测量值外，其余空间频率测量结果与平板微机RCSF测定仪的测量结果相比差异均无统计学意义（均为P〉0．05）。33眼白内障患者中有19眼术前无法用样机测出最佳矫正视力，术前和术后最佳矫正视力之间具有相关性（r=0．382，P=0．028）。〉20～40岁组、〉40—60岁组和〉60～80岁组，术前与术后视力测量一致性分别为34．4％、53．7％和25．9％。结论具有干涉视力计功能的手持式RCSF测量样机具有较好的移动性、良好的测量稳定性和有效性，不但可以用于测量RCSF，且具有良好的干涉视力计测量功能。

Objective To study and produce a novel hand-held instrumental pro- totype measuring retinal contrast sensitivity function （CSF）with function of interferom- eter,and investigate its efficiency and repeatability in clinic. Method Three instru- mental prototype measuring retinal-CSF with function of interferometer were produced, the retinal CSF and visual acuity of 48 normal eyes and 33 eyes with cataract were measured two-times each before surgery. The differences of retinal CSF between two groups was analyzed by t test, and the correlation between preoperative and postopera- tive visual acuity was also analyzed by Pearson analysis. Results In the 48 normal eyes under spatial frequency of 2.4 c·d^-1,3.6 c·d^-1,6.0 c·d^-1,9.0 c ·d^-1, 15.0 c·d^-1 and 24.0 c·d^-1 ,the inconsistency of two-times measurement was 0,0,2, 4,4,9,the rate of consistency was 100% ,100% ,95.8% ,91.7% 91.7% ,81.3% ,respec- tively, the measurement consistency （ except for 24.0 c·d^-1） with results measured by digital parallel-based retinal CSF instrument was significant （ all P 〉 0.05 ）. Out of 33 eyes with cataract,visual acuity in 19 eyes could not be measured. The correlation be- tween preoperative and postoperative visual acuity was positive （ r = 0.382 ,P = 0.028 ）. Among groups of 20 -40 years old,40 -60 years old and 60 -80 years old, the consisten- cy of preoperative and postoperative visual acuity was 34.4% , 53.7% and 25.9% , re- spectively. Conclusion The hand-held prototype of retinal CSF with function of in- terferometer have the amazing mobility,stability and efficiency,which can be efficiently applied in measuring retinal CSF and potential visual acuity as well.