点状内层脉络膜病变研究进展

Research progress in punctate inner choroidopathy

点状内层脉络膜病变(punctate inner choroidopathy,PIC)好发于中高度近视的青年女性,通常以视力下降、视物模糊和闪光感为主要临床表现。PIC早期较少对视力产生损害,因此大多数患者无需就诊,部分患者随病情发展并发脉络膜新生血管时会迅速出现视力下降,需要及时治疗。PIC治疗方法有多种,但对于有效的治疗方法,目前没有明确的共识,因此未来需进一步研究PIC的病因和病理机制,以便采取有效的治疗方法取得显著疗效并最大可能地减少并发症的发生。

Punctate inner choroidopathy （PIC） usually appears in young myopic fe- males, and present with vision loss, blurred vision and flashing. Most patients with PIC do not require treatment, as the disease does not often threaten vision early, however, when subfoveal choroidal neovascular membrane ensues, some of the cases usually lose sight rapidly,requiring immediate care. There are a variety of treatments for PIC,inclu- ding systemic and local steroids, immunosuppressant agents, surgery, laser photocoagu- lation,photodynamic therapy,anti-vascular endothelial growth factor therapy or combi- nation therapy. To date, however, there is no clear consensus on the effective therapy. Further research into this area, as well as on the cause and possible predisposing factors for PIC, is warranted, in order to maximize the therapeutic effects and minimize the complications.