对烧伤脓毒症相关问题的认识

An inquiry into the relevant issues about burn sepsis

目前，脓毒症仍然是导致烧伤患者救治失败的最主要原因。1989年，Balk和Bone在《CritCareClin}杂志中提出脓毒症定义设想，他们随后牵头，在1992年美国胸科医师协会／危重病医学会会议上正式发布脓毒症定义。该定义发布20余年来，为危重烧伤治疗带来了新的理念和方法，使得烧伤学与危重病学的结合愈加紧密。本文结合脓毒症定义与国际脓毒症治疗指南，进一步梳理危重烧伤脓毒症治疗过程中的相关问题。

Since the definition of sepsis was proposed in Chest hy American College of Chest Physicians and Society of Critical Care Medicine in 1992, researches on burn sepsis have focused on the regulation of immune-inflammation response re- suiting in minimizing tissue injury resulted from excessive in- flammatory response. Treatment of sepsis should focus on effect of early circulation oxygenation support in preventing and treating multiple organ dysfunction. The hypothesis of producing a hiber- nation-like state which might prevent multiple organ dysfunction in patients with sepsis provides us a new therapeutic strategy in protecting organs in the early stage of sepsis in future.