高湿度对地衣芽胞杆菌胶囊质量的影响

Influence of High-Humidity on the Quality of the Bacillus licheniformis Capsules

目的:探讨环境湿度对微生态制剂质量的影响。方法:以微生态制剂地衣芽胞杆菌胶囊为研究对象,在模拟的高湿度环境中研究了其干燥失重、活菌数和崩解时限的变化。结果:在相对湿度为80%的环境中放置48 h后,药品的活菌数、干燥失重、崩解时限均有显著变化。结论:高湿对益生菌制剂质量有很大影响,该类制剂应严格遵循药品贮存和使用的条件,并注意密闭包装。

Objective： To study the influence of environment humidity to the probiotics. Methods： Taking Bacil lus licheniformis capsule as investigated subject, the changes of drying loss, survival number and disintegration time limit under a model high-humidity condition were observed. Results： Compared with normal conditions, the live bacteria number of the Bacillus licheniformis capsules were reduced significantly after 48 h on 80% humidity environment. Conclusion： The high humidity has significant impact on probiotie product. So probiotic product should be instriet accordance with the storage and use condition, and keep in tight packs.