摘要
炎症部位白细胞聚集和活化是炎症性肠病(IBD)的重要特征,趋化因子受体是趋化白细胞的重要调节因子。在IBD中,多种趋化因子受体表达上调,触发多种炎症反应。本文就CC趋化因子受体(CCR)在IBD中的作用及其作为IBD治疗靶点的可能性作一综述。
Leucocytes aggregation and activation at inflammatory sites are important features of inflammatory bowel disease （IBD）, and ehemokine receptors are the essential regulatory factors for chemoattracting leucocytes. Many chemokine receptors are up-regulated and trigger various types of inflammation in IBD. In this review article, the role of CC chemokine receptors （CCR） in IBD and its potential to be the therapeutic target of IBD was discussed.
出处
《胃肠病学》
2014年第1期50-53,共4页
Chinese Journal of Gastroenterology
基金
国家自然科学基金面上项目(81370499)资助
关键词
趋化因子
CC
受体
CCR
炎症性肠病
Chemokines, CC
Receptors, CCR
Inflammatory Bowel Disease
