PPARγ磷酸化与非磷酸化的研究进展

Research Progress of Phosphorylation and Non-phosphorylation of PPARγ

过氧化物酶体增殖物激活受体γ(PPARγ)是一种配体依赖性核转录因子,具有调控细胞分化、脂肪代谢、糖代谢及炎症等多种生物学功能。已知PPARγ有多种转录后修饰,磷酸化修饰是PPARγ第一个被鉴定的翻译后修饰方式,目前研究较多的是Ser112位点的丝裂原激活的蛋白激酶途径及Ser273位点的细胞周期素依赖的蛋白激酶5途径。PPARγ的异源二聚体结合到靶基因启动子区的特异反应元件过氧化物酶体增殖反应元件上调控靶基因的转录,PPARγ还参与炎性反应应答。PPARγ与糖尿病、肿瘤等疾病也有密切的联系。

Peroxisome proliferator activated receptor-γ（PPARγ） is a ligand-dependent transcription factor,which can regulate cell differentiation, lipid metabolism, glucose metabolism and inflammation and other biological functions. It is known that PPARγ has a variety of post-translational modifications,and phos phorylation is the first identified post-translational modification of PPARγ. The current studies on Ser112 site of the MAPK pathway and Ser273 site of the Cdk5 pathway are popular. The heterologous dimerization of PPARγ can bind to the target gene promoter region specific response element PPRE（ peroxisome proliferator response elements） to regulate the transcription of the target genes. In addition ,PPARγ is also involved in the inflammatory response, and is closely linked to diabetes, cancer and other diseases.