社居福利因素对小鼠生长发育及繁殖性能的影响

Effects of association factor on growing development and reproductive performance of mice

目的探讨社居福利因素对实验小鼠生长发育及繁殖性能的影响。方法选取6—8周龄ICR小鼠，通过对其社会、群体、交配、密度等不同因素的干预，观察对其生长发育及繁殖性能的影响。结果第1胎时，各组雌鼠的各项繁育指标均无显著差异。第2、3胎时结果类似，各组雌鼠产仔数无显著差异（P〉0．05），A组（1：1交配同居组）的仔鼠的离乳率和离乳体重均显著高于其他实验组（P〈0．01），D组（21：1交配非同居组）的仔鼠离乳体重明显低于其他实验组（P〈0．01）。F组（3只组）的28、35、42日龄体重均高于其他3组，28日龄时与E组（单只组）和G组（6只组）差异显著（P〈0．05），35、42日龄时只与E组有差异（P〈0．05）。F组22-28d、29～35d和36～42d的体重增长均高于其他组，但与G组无显著差异（P〉0．05），F组和G组的36～42d的体重增长都与E组差异显著（P〈0．05）。H组（12只组）的日龄体重及体重增长均低于其他组（P〈0．01）。结论社居福利因素对ICR小鼠的生长发育及繁殖性能有一定程度的影响。在实验小鼠的饲养管理过程中应引起注意。

Objective To study the effects of association factor on growing development and reproductive performance of experimental mice. Methods ICR mice were fed under different association factor, mating ways and crowded condition, and the number of newborn mice, delivery rates and body weight at different times were recorded. Results The reproductive performance of the 1st fetal showed no significant difference between different groups （P 〉 0. 05）. And the one of the 3rd fetal was similar to the 2nd fetal , the comparison of the number of newborn mice between different groups showed no significant difference （P 〉 0.05）. The delivery rates and delivery body weight of newborn mice of group A were significant higher than the other groups （P 〈 0. 01 ） , and the delivery body weight of newborn mice of group D were significant lower than the others （P 〈 0.01 ）. The body weight of group F was higher than all the other groups. The one which was significant different from group E and G at 28 days （ P 〈 0. 05） , just showed significantdifference between group E at 35 and 42 days （P 〈 0. 05）. The increasing body weight of group F were higher than all the other groups at different times , but showed no significant difference between group G （P 〉 0. 05）. The increasing body weight of group F and G both showed significant difference between group E （ P 〈 0. 05 ） during 36 to 42 days. All results of group H were significant lower than the others （P 〈 0.01 ）. Conclusion Association Factor may has the effect on growing development and reproductive performance of mice, and should be paid attention to during the process of feeding and managing experimental mice.