摘要
目的:探讨SPECT脑血流灌注显像联合血清S100β蛋白的检测在血管性认知障碍无痴呆(VCIND)诊断中的应用价值。方法:收集VCIND患者60例为VCIND组,30例体检合格者为对照组,对2组进行一般检查、神经功能评定、脑SPECT检查局部脑血流量(rCBF)和血清S100β蛋白含量检测。结果:与对照组比较,VCIND组双侧额叶、左侧顶上小叶、左侧丘脑rCBF明显降低(P<0.05);左侧额叶、左侧顶上小叶、左侧丘脑均较右侧rCBF明显降低(P<0.05);VCIND组血清S100β蛋白含量明显升高(P<0.05)。结论:SPECT脑灌注显像联合血清S100β蛋白检测对早期发现VCIND患者具有重要的临床价值。
Objective：To explore the application of SPECT combined with serum S 100β protein in the diagnosis of vascular cognitive impairment but not dementia （VCIND）. Methods： Sixty VC1ND patients （VCIND group） and 30 healthy persons （control group） have been evaluated by general examination, nerve function evaluation, brain SPECT examination and serum S100βprotein content detection. Results： Compared with the control group, rCBF in the bilateral frontal lobes, left superior lobule, and the left thalamus of VCIND group was decreased significantly （P〈0.05）. Compared with the right side, rCBF in the frontal lobe, superior lobule, and the thalamus on the left side were decreased significantly （P〈0.05）. The serum S100β protein content in the VCIND group was increased significantly compared with that in the control （P〈0.05）. Conclusion： SPECT cerebral perfusion imaging combined with serum S100β protein detection is effective in the early diagnosis of VCIND patients.
出处
《神经损伤与功能重建》
2014年第1期36-39,共4页
Neural Injury and Functional Reconstruction
基金
安徽省卫生厅课题(No.13zc032)
