丙型病毒性肝炎与酒精性肝病的研究现状

Research progress of hepatitis C and alcoholic liver disease

随着生活水平的提高,生活方式的改变,饮酒人数的增加,酒精性肝病(alcoholic liver disease,ALD)和肥胖导致的非酒精性肝病是仅次于病毒性肝炎的第二大类肝病,已成为比较严重的公共社会问题[1-2]。90%进入体内的酒精在肝内代谢,正常人每日可代谢120g酒精,长期饮酒使肝细胞反复发生脂肪变性、坏死和再生,最终引起ALD。ALD临床可分为酒精性脂肪肝、酒精性肝炎和酒精性肝硬化。大多数单纯酒精性脂肪肝患者,尤其年轻者,没有症状。10%~20%的酗酒者均有不同程度的ALD。慢性丙型肝炎(chronic hepatitis C,

Alcoholic liver disease （ALD）and obesity-caused non-alcoholic liver disease are in a rising trend. ALD has become the second popular disease following the viral liver disease. A total of 90 % intaken alcohol were metabolized in the liver; long term alcohol consumption would induce liver cells to fat degenera tion, necrosis or even regeneration, and ultimately lead to ALD. Hepatitis C virus （HCV） infection is usually concealed and can gradually develop into cirrhosis and liver cancer. HCV infection plus alcoholism or ALD concurrently infected HCV can accelerate the development and progression of liver disease such as chronic hepatitis, cirrhosis and hepatocellular carcinoma. In this review, we summarize the research progress in epidemiology of alcoholic liver disease and chronic hepatitis C, the mutual influence between the two diseases, mechanisms of action, prognosis and antiviral therapy for hepatitis C infection.