541例食管癌临床病理特点及相关蛋白的表达意义

Clinicopathological characteristics of esophageal cancer and the significance of the expressions of related proteins in 541 patients

目的探讨河南地区食管癌临床病理流行特点及与相关蛋白的关系。方法回顾性分析541例手术切除标本并经组织病理检查确诊的食管癌患者的临床与病理资料。结果 541例食管癌患者中,男363例,女178例;镜检确诊鳞癌519例(占95.9%);TNM分期Ⅱ期64.33%、Ⅳ期少见;发病部位位于胸上段65例、中段385例、下段91例;淋巴结有转移者血清表皮生长因子受体及P53蛋白阳性率高于无转移者,低分化患者簇分化抗原56高于中高分化者,中晚期患者血清Ki67阳性率高于早期患者(P<0.05)。结论河南地区食管癌患者肿瘤好发部位多为胸中段,下段次之,上段最少;男性患者多于女性,早期病例就诊少;表皮生长因子受体、簇分化抗原56、Ki67在食管癌患者癌组织中表达增多,可能与食管癌恶性程度及侵袭、转移程度有关。

Objective To explore the clinicopathological characteristics of esophageal cancer in Henan and its relationship with related proteins. Methods The pathological data of 541 patients with histopathologically confirmed esophageal cancer were retrospectively analyzed. Results In 541 patients, 363 were males and 178 were females. Microscopy confirmed squamous cell carcinoma in 519 cases （95.90//00）. TNM stage [I accounted for 64.33%, and fewer patients were found in stage IV. The focus was most commonly located at upper thoracic part in 65 patients, middle part in 385 patients, and lower part in 91 patients. The expression of epidermal growth factor receptor （EGFR） increased in lymph node metastasis group than that in non-metastasis group, the level of cluster differentiation antigen 56 （CD56） was higher in poor-differentiated group than that in well-differentiated group, and the positive rate of Ki67 was higher in advanced group than that in early group （P^0.05）. Conclusions The esophageal cancer is mostly located at middie thoracic part, followed by lower part, and is seldomly found at upper part in Henan. Male patients are more than female patients. Fewer patients in early stage visit hospital. The expressions of EGFR, CD56 and Ki67 increase in esophageal carcinoma patients, which may be associated with the degrees of esophageal malignancy, invasion and metastasis.