IL-17、IL-23在口腔扁平苔藓患者外周血中的表达及相关性

Expression and correlation of IL-17 and IL-23 in peripheral blood in patients with oral lichen planus

目的:研究IL-17和IL-23基因在口腔扁平苔藓(OLP)患者外周血中的表达水平。方法:采用实时荧光定量RT-PCR方法,检测30例OLP患者和30例健康人外周血中IL-17和IL-23的基因表达水平。结果:IL-17和IL-23 mRNA在口腔扁平苔藓患者外周血中高于健康人(P<0.05);IL-17和IL-23的表达水平呈正相关(r=0.34,P=0.017)。结论:IL-17和IL-23在口腔扁平苔藓的发病中发挥了一定的作用。

Objective： To study the expression of IL-17 and IL-23 genes in peripheral blood of patients with oral lichen planus （OLP）. Methods： Expression levels of IL- 17 and IL-23 mRNA in peripheral blood of 30 OLP patients and 30 heahhy subjects were detected by real-time fluorescent quantitative RT-PCR method and statistically analyzed. Results： IL-17 and IL-23 levels were higher in OLP patients than those in the healthy controls （P 〈 0.05）. The expression of IL-17and IL-23 showed a positive correlation （r = 0.455 0, P =0.011 5 〈0.05）. Conclusion： IL-17 and IL-23 might play a role in oral lichen planus pathogenesis.