米托蒽醌为主中西医结合治疗急性白血病临床观察

Clinical observation on the integration of traditional and western medicine given first place to mitoxantrone for treatment in acute leukemia

目的：观察米托蒽醌及中西医结合治疗急性白血病的临床疗效。方法：将６０ 例急性白血病患者随机分为两组，对照组２７例，采用米托蒽醌为主的联合化疗；治疗组３３例，在用米托蒽醌为主联合化疗的基础上，加用健脾和胃，清热解毒中药。结果：治疗组获完全缓解（ＣＲ）２１例，部分缓解（ＰＲ）１０例，总有效率９３．９４％，明显优于对照组７０．３７％（Ｐ＜０．０５），且临床未见明显毒副反应。结论：米托蒽醌为主联合方案治疗急性白血病疗效良好，毒副反应较轻，合用健牌和胃、清热解毒中药，可提高疗效，减轻毒副反应。

Objective It is to observe the clinical effect of Mitoxantrone (MTZ)and the integration of traditional Chinese and western medicine in treating acute leukemia. Methods: Sixty patients were randomly divided into two groups: 27 patients of the control group were treated with mainly MTZ combined chemotherapy, 33 patients of the treated group were treated with traditional chinese medicine invigorating the spleen and regulating stomach-energy, clearing away heat and toxic materials on the basis of the protocol therapy in the control group. Results: 21 patients achieved complete remission (CR), 10 patients partial remission (PR) in the treated group. Total effective rate was 93.94%, better than 70.37% of the control group (P<0.05)and had no toxic side-effect. Conclusion:These data showed that mainly MTZ combined chemoterapy is effective and the toxic side -effect is low for acute leukemia. These therapy combined chinese medicine could increase curative effect and reduce the toxic side-effect.