摘要
目的探讨血清her-2和cox-2浓度与非小细胞肺癌(NSCLC)患者临床病理特征和长期预后之间的关系。方法采用ELISA法检测非小细胞肺癌组221例,肺部良性疾病组41例血清中her-2和cox-2浓度,比较不同患者血清her-2和cox-2浓度差异,探讨两者的相关性及对预后的影响。结果 her-2和cox-2在非小细胞肺癌患者血清水平明显高于肺部良性疾病患者,差异均有统计学意义(P<0.05);且均与肿瘤分期呈正相关(Spearman秩相关系数r分别为:0.830,0.719,P<0.05)。单因素分析显示血清her-2和cox-2浓度的表达均与患者生存有密切关系(P<0.05);多因素分析显示血清her-2和cox-2浓度均不是影响预后的独立危险因素,而两者联合检测可预测病人的预后相对危险度为1.5(1.08-2.09)。结论非小细胞肺癌患者血清中her-2和cox-2阳性表达明显相关。两者的联合检测有助于非小细胞肺癌的预后评估。
Objective To investigate the correlations of serum her-2 and cox-2 levels with clinical pathological characteristics and Long-term prognosis in patients with non-small cell lung cancer （NSCLC）.Methods Enzyme-linked immunoadsorbent assay （ELISA） was used to detect the levels of her-2 and cox-2 in the serum samples collected from 221 NSCLC patients and 41 controls.The concentrations of her-2 and cox-2 were compared between different patients,and there correlations as well as their influences on prognosis were also analyzed.Results The levels of serum her-2 and cox-2 were significantly higher in the NSCLC patients than those in the controls（P〈0.05）,which were also positively correlated tumor stages （Spearman＇s rank correlation coefficient r：0.830,0.719,P〈0.05）.Univariate analysis showed that serum concentrations of both her-2 and cox-2 expression were closely correlated with survivals of the patients（P〈 0.05）.Multi-factor analysis showed that both her-2 and cox-2 concentrations in the serum were not independent risk factors influencing prognosis,but their combination can predict the prognosis of patients 1.5 （1.08-2.09）.Conclusion Serum levels of her-2 and cox-2 expression are significantly correlated in NSCLC patients,and combined detection for their expression may be of important value in judgment of prognosis.
出处
《中国实验诊断学》
2014年第2期227-230,共4页
Chinese Journal of Laboratory Diagnosis
基金
烟台市科学技术发展计划项目(项目编号:2009156-3)
