环丝氨酸治疗耐药结核菌患者的效果观察

Effect of cycloserine on the patients underwent drugs resistant bacillus tuberculosis

目的:观察环丝氨酸治疗耐药结核菌患者的效果。方法:选择100例耐药结核病患者,随机分为两组:环丝氨酸组和对氨基水杨酸组,分别应用环丝氨酸和对氨基水杨酸。记录两组治疗后3个月、6个月、12个月、24个月痰菌阴转的患者例数,记录两组治疗结束时X线胸片病灶吸收情况,记录两组患者的不良反应。结果:治疗后两组患者在各个阶段的阴转率比较差异均无统计学意义(P>0.05)。病灶吸收率两组比较差异无统计学意义(P>0.05)。环丝氨酸组患者的肝功能损伤发生率明显低于对氨基水杨酸组患者(P<0.05),其他不良反应两组患者发生率比较,差异无统计学意义(P>0.05)。结论:环丝氨酸治疗耐药结核菌患者的效果良好,不良反应少。

Objective To observe the effect of cyclosefine on the patients underwent drugs resistant bacillus tuberculosis. Method One hundred patients underwent drugs resistant bacillus tuberculosis were divided into two groups： eycloserine group and p - aminosalicylic acid group. The patients in beth groups were administrated with cycloserine and p - aminosalicylic acid respectively. The number of sputum nega- tive conversion after 3 months ,6 months, 12 months,24 months of treatment were recorded in both groups. The X - ray chest radiograph le- sions absorption and complication in both groups were recorded. Results There were no significant difference in sputum negative conversion and X - ray chest radiograph lesions absorption（ P 〉 0. 05 ）. The incidence of liver damage in cycloserine group was lower than it in p - aminosalicylie acid group （P 〈 0. 05 ） . Other complication were not significantly different between two groups （P 〉 0. 05 ）. Conclusion Cycloserine is effect for the patients underwent drugs resistant bacillus tuberculosis and its complication are few.