百草枯中毒患者脑脊液中NSE和S-100β的变化及意义

The changes and clinical significance of NSE and S-100β in cerebrospinal fluid in the patients with acute paraquat poisoning

目的:探讨急性百草枯中毒患者脑脊液中神经元特异性烯醇化酶(NSE)和S-100β蛋白(S-1O0β)水平变化及其临床意义。方法:检测36例急性百草枯中毒患者脑脊液中NSE和S-100β水平的变化,与20例对照组比较分析。结果:中毒组脑脊液中NSE和S-l00β的水平均显著高于对照组(均P<0.01);死亡组脑脊液中NSE和S-l00β的含量均明显高于存活组(P<0.01或P<0.05)。结论:脑脊液中NSE和S-100β水平的变化,可作为评估急性百草枯中毒患者脑组织损伤及其严重程度的临床指标。

Objective To explore the change and clinical significance of NSE and S - 10013 in cerebrospinal fluid in the patients with a- cute paraquat poisoning. Method The levels of NSE and S - 10013 in cerebrospinal fluid in the patients with acute paraquat poisoning and 20 controls were tested. Results The levels of NSE and S - 10013 in eerebrospinal fluid in the poisoning groups were siganifieantly higher than those in control group（ P 〈0. 01 ）. The levels of NSE and S - 10013 in eerebrospinal fluid in the death group were siganifieandy higher than those in the survival group （P 〈0. O1 or P 〈0. 05）. Conclusion The levels of NSE and S - 10013 in eerebrospinal fluid may serve as clinical indexes of evaluating the degrees of the brain tissue damage by the aeute paraquat poisoning.