健脾磨积汤治疗失代偿期丙型肝炎肝硬化临床疗效观察

Effects of “Jianpi Moji Decoction”on hepatitis C decompensated cirrhosis

目的观察健脾磨积汤治疗失代偿期丙型肝炎肝硬化的临床疗效。方法将60例失代偿期丙型肝炎肝硬化患者随机分为治疗组和对照组。两组患者均予常规保肝、对症、支持治疗,治疗组同时加用健脾磨积汤,疗程为6个月。观察两组临床疗效、肝功能、肝纤维化指标、B超声像图的变化。结果治疗组和对照组总有效率分别为90.0%、63.3%;组间临床疗效差异有统计学意义(P<0.05)。治疗组治疗后肝功能(ALB、TBIL)、肝纤维化指标(PC-Ⅲ、LN)、B超声像图(脾厚度、门静脉内径、脾静脉内径)均有改善,与对照组比较差异有统计学意义(P<0.05)。结论健脾磨积汤能提高失代偿期丙型肝炎肝硬化的临床疗效。

Objective To observe the clinical efficacy of ＂Jianpi Moji Decoction＂ in treating hepatitis C decompensated cirrhosis. Methods Sixty cases with hepatitis C decompensated cirrhosis were randomized into treatment group and control group. Cases in both of the groups were treated by conventional therapy, and cases in treatment group were treated with ＂Jianpi Moji Decoction＂, with the course of 6 months. The clinical efficacy, liver function, liver fibrosis indexes and B ultrasonogram were detected. Results The total effective rate was 90% in the treatment group and 63.3% in the control group, with significant differences between the two groups（ P 〈 0.05 ） ; after treatment, there were significant differences in liver function （ ALB, TBIL） , indicators of hepatic fibrosis （ Pc-m, LN）, B uhrasonography （spleen thickness, partal vein diameter, diameter of splenic vein） between treatment group and control group （P 〈 0.05 ）. Conclusion ＂Jianpi Moji Decoction＂ can improve clinical efficacy of hepatitis C decompensated cirrhosis.