肿瘤坏死因子-α和白介素-6与病毒性肝炎肝纤维化的关系

Relationship between Tumor Necrosis Factor (TNF-α), Interleukin-6 (IL-6) and Liver Fibrosis

目的与方法 将 83例慢性病毒性肝炎及肝硬化患者肝穿取得的肝组织 ,按纤维化程度分期 ,应用ELISA法检测其血清TNF -α和IL - 6水平。结果 血清TNF -α和IL - 6水平在肝纤维化S2 、S3及S4 期比正常对照组明显升高 (P <0 0 0 1) ,且随着纤维化程度的加重而不断升高。血清TNF -α和IL - 6水平与血清HA、HPCⅢ、LN及IV -C水平呈低～中度的正相关 (P <0 0 1) ;与肝组织纤维化程度计分呈中～高度的正相关 (P <0 0 0 1)。结论 血清TNF -α和IL - 6水平与肝纤维化程度密切相关 ,TNF -α和IL - 6参与了肝纤维化的形成和发展。

Objective: To discuss the relationship between TNF-α, IL-6 and liver fibrosis. Methods: 83 cases of chronic liver disease patients were divided into different groups according to the pathological differentiation of liver fibrosis with puncture biopsy. The serum TNF-α and IL-6 of patients were detected with ELISA method. Results: TNF-α and IL-6 level of liver fibrosis in S, S and S were obviously increased than those of normal group (p<0.001) and gradually increased with fibrosis aggravation. The serum TNF-α, IL-6 was low or moderate positive correlated with serum HA, HPCIII, LN and IV-C level. They were moderate or high positive correlated with the degree of liver fibrosis. Conclusion: The serum TNF-α and IL-6 levels might be related closely with liver fibrosis and participate in fibrosis formation and development.