进展期胃肠癌患者围手术期能全素-5Fu的应用及对免疫状态的影响

Application and Immune Effect of Nutrison-5Fu on Perioperative Patients with Progressive Gastrointestinal Cancer

目的 研究与评价能全素 - 5Fu治疗对进展期胃肠癌患者围手术期免疫状态的影响并介绍其应用方法。方法 确立免疫指标及正常值 ,将 78例患者随机分为⑴能全素 - 5Fu组 :给予能全素 - 5Fu治疗 ;⑵单纯化疗组 :给予 5-Fu治疗 ;⑶对照组 :围手术期内不予化疗与免疫治疗。三组分别测定围手术期各阶段T细胞亚群与NKCC值。结果 各组治疗前CD3、CD4 、CD4 /CD8、NKCC值均有明显下降 ,应用能全素 - 5Fu后 ,上述数值均明显升高 ,单纯化疗者则明显下降。结论 能全素 - 5Fu治疗既可抑制肿瘤的生长 。

Objectives To investigate and evaluate the effect of Nutrison-5Fu on immune function of perioperative patients with progressive gastrointestinal cancer,and simultaneously we also recommended the methods of application of Nutrison-5Fu.Methods Seventy eight cases were equally divided at random into three groups,26 cases in each group.⑴Nutrison-5Fu group:the patients were treated with Nutrison-5Fu.⑵Chemotherapy group:the patients only received 5-Fu.⑶Control group:there were not any chemotherapy and immunetherapy during the perioperation.The values of CD 3,CD 4,CD 8 and NKCC were determined in all cases.Results Values of CD 3,CD 4,CD/CD 8 ratio and NKCC in most patients were distinctly low,but the condition rapid improved by giving them Nutrison-5Fu.On the contrary,the values declined further after chemotherapy alone.Conclusion The treatment of Nutrison-5Fu not only can repress the development of the tumor,but also can improve the dystrophic status and immune function of the patients with cancer.