茶色素治疗消化性溃疡临床疗效观察

Clinical study on therapeutic effect of tea pigment on peptic ulcer

目的 评估茶色素治疗消化性溃疡的临床疗效。方法 10 0例经胃镜诊断的消化性溃疡患者 ,随机分成两组 ,每组5 0例 ,采用双盲对照观察。治疗组 :茶色素 2 5 0mg ,2次 /日 ;对照组 :雷尼替丁 15 0mg ,2次 /日。 4周后胃镜复查。结果 10 0例消化性溃疡患者 ,失访 5例 (治疗组 3例 ,对照组 2例 ) ,95例完成治疗和胃镜复查。根据意图治疗分析 (ITT) ,治疗组治愈率为 80 % (42 /5 0 ) ,对照组治愈率为 88% (44 / 5 0 )。两组治愈率经统计学处理无显著差异 (P >0 5 )。对照组出现 4例AST轻度升高 ,治疗组未见副作用发生。结论 茶色素治疗消化性溃疡有良好的效果。

Aim To observe the therapeutic effect of tea pigment on peptic ulcer.Methods One hundred patients with peptic ulcer endoscopically diagnosed were randomly assigned to two groups,each group was fifty cases.Dobule-blind control was adopted.Therapy group:tea pigment 250 mg,bid;control group:ranitidine 150 mg,bid.After four weeks,they were rechecked endoscopically.Results Five patients dropped out (3 in therapy group,2 in control group).Based on intention-to-treat analysis,the healing rates in therapy group and control group were 80% (42/50),88%(44/50) respectively.There were no significant differences between therapy group and control group (P>0.5).Conclusion Tea pigment has better therapeutic effect on peptic ulcer.