CagA^+ Hp感染与消化性溃疡

CagA^+ Hp infection and peptic ulcer

目的 本文旨在探讨十二指肠球部溃疡、胃溃疡等与产细胞毒相关蛋白A幽门螺旋杆菌 (CagA+ Hp)感染的关系。方法 分为三组 :即无症状对照组、十二指肠球部溃疡及胃溃疡组 ,Hp感染以快速尿素酶试验 (RUT)、14 C—呼气试验 (14 C—URT)和(或 )病理特殊染色确定 ,CagA+ Hp感染则进一步通过检测血清CagAIgG加以确定。分别计算各组Hp及CagA+ Hp的感染率及Ca gA+ Hp占Hp感染的比例 ,并作组间比较。结果 消化性溃疡时 ,Hp及CagA+ Hp的感染率以及CagA+ Hp与Hp感染者之比率均明显高于正常对照组 ,统计学差异显著 (P <0 0 1)。结论 Hp与十二指肠球部溃疡及胃溃疡的发生高度相关 ,其感染率达 90 %以上 ,其中产CagA型Hp又占九成以上 ,可见CagA+ Hp感染与消化性溃疡关系密切 ,这在消化溃疡的防治中应引起足够的重视。

Aim To study the relationship between serum CagA protein positive Helicobacter Pylori(CagA+Hp) infection and peptic ulcer such as duodenal ulcer and gastric ulcer(GU).Methods The sample was divided into three groups:group asymptomatic control(group AC)、group DU and group GU.Infection was confirmed by rapid urease test(RUT)and 14C-urea breath test( 14*'C-UBT)or (and)by pathological staining,CagA+Hp infection was confirrned by further detecting of serum anti-CagA IgG.Results The prevalence of H.pylori and CagA+Hp in group DU and GU is much higher than that in group AC, (P<0.01),and so was it with the ratio of the patients with CagA+Hp infection to that with Hp infection.Conclusions The high prevalence of CagA+Hp infection exists in patients with H.pylori associated GU or DU,while the infection rate of CagA+Hp is less than 25%in the asymptomatic control,these data suggest CagA+Hp play an important role in the pathogenesis of peptic ulcer and the detection of CagA+Hp may be a valuable sign for the treatment and prevention of the associated diseases.