摘要
采用乳化-溶剂挥发法,以可生物降解材料聚乳酸为载体,在其中加入医药级阿奇霉素和一定量纳米四氧化三铁制备聚乳酸/纳米四氧化三铁载阿奇霉素缓释微球,通过正交实验优化了制备工艺,并研究了微球的释药行为。结果表明,微球具有明显的药物缓释作用。
PLA/Nano-Fe3 O4-AZM-MS （microsphere of PLA/nano-Fe3O4 loading azithromycin） was pre- pared by emulsification-solvent evaporation method from medicinal azithromycin（AZM） and nano-Fe2o3 with biodegradable material polylactie aeid（PLA） as carrier. The preparation conditions were optimized through or- thogonal experiment. And drug release behavior of PLA/nano-Fes O4-AZM-MS was also studied. The results showed that PLA/nano-Fes O4-AZM-MS possessed obvious drug release property.
出处
《化学与生物工程》
CAS
2014年第2期35-37,共3页
Chemistry & Bioengineering
基金
陕西国防工业职业技术学院研究与开发项目(Gfy13-25)
